";s:4:"text";s:4586:" Among 43 functional heartburn and esophageal hypersensitivity patients randomized to treatment with 25 mg qhs imipramine and 40 randomized to matched placebo, … In another study, citalopram, an SSRI, was shown to lower chemical stimulation (discomfort during < 15 min of esophageal acid perfusion) and mechanical hypersensitivity (discomfort during < 10 mL esophageal balloon distention) without changing esophageal motility. Unable to load your collection due to an error Keywords: Chest pain, Esophagus, Functional esophageal disorder, Heartburn, Reflux hypersensitivity…
Functional esophageal disorders consist of a disease category that presents with esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not explained by mechanical obstruction (stricture, tumor, eosinophilic esophagitis), major motor disorders (achalasia, esophagogastric junction outflow obstruction, absent contractility, distal esophageal spasm, jackhammer esophagus), or gastroesophageal reflux disease. Although mechanisms responsible are unclear, it is theorized that visceral hypersensitivity and hypervigilance play an important role in symptom generation, in the context of normal or borderline function.
However, outcome data from these treatment options are limited. BACKGROUND/AIM: The treatment of esophageal (noncardiac) chest pain is unsatisfactory and there is no approved therapy. On the positive side, imipramine treatment was associated with improvement in quality of life as assessed by total SF-36 score.
Among 43 functional heartburn and esophageal hypersensitivity patients randomized to treatment with 25 mg qhs imipramine and 40 randomized to matched placebo, the response rates, judged by a 50% reduction in gastroesophageal reflux disease symptoms, were 37.2% and 37.5%, respectively, with no observed difference between patients with hypersensitivity and those with functional heartburn.
Limsrivilai et al. Psychological and complementary/ alternative therapies have also been used. Surgical anti-reflux management may also play an important role in the treatment of reflux hypersensitivity. 2014 Feb;26(2):187-95. doi: 10.1111/nmo.12251. Epub 2013 Nov 4.Curr Opin Gastroenterol. Our aims were to investigate the effects of theophylline on esophageal sensorimotor function and chest pain. Epub 2016 Jan 12.Limsrivilai J, Charatcharoenwitthaya P, Pausawasdi N, Leelakusolvong S.Am J Gastroenterol.
report on a randomized control trial (RCT) testing the efficacy of imipramine for treating esophageal hypersensitivity and functional heartburn, the first RCT to test this therapy in this indication.
Medical treatment may entail medication such as nerve modulators and acid medication.
Wolters Kluwer
Epub 2016 Jan 12.Forcelini CM, Tomiozzo JC Jr, Farré R, Van Oudenhove L, Callegari-Jacques SM, Ribeiro M, Madalosso BH, Fornari F.Neurogastroenterol Motil.
In some cases, the doctor may even recommend surgery. Unable to load your delegates due to an error 2016 Jul;111(7):1035-6. doi: 10.1038/ajg.2016.104.
Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. The mainstay of treatment of esophageal hypersensitivity is with pain modulators including TCAs, SSRIs, serotonin noradrenergic reuptake inhibitors, and gabapentenoids, as described in Table 1.
Limsrivilai J, Charatcharoenwitthaya P, Pausawasdi N, Leelakusolvong S.Am J Gastroenterol. Name must be less than 100 characters METHODS: In a double-blind study, sensory and biomechanical … The best treatment for esophageal hypersensitivity depends on the type of esophageal hypersensitivity the patient has. A previous uncontrolled study suggested that theophylline may be useful. 2016 Feb;111(2):217-24. doi: 10.1038/ajg.2015.413.
Treatments directed at improving borderline motor dysfunction or reducing reflux burden to subnormal levels have limited success in symptom improvement.