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1979 Jul;26(1):103-13. doi: 10.1002/cpt1979261103.Greenblatt DJ, Joyce TH, Comer WH, Knowles JA, Shader RI, Kyriakopoulos AA, MacLaughlin DS, Ruelius HW.Clin Pharmacol Ther.
Absorption or oral and sublingual lorazepam tended to be less rapid than intramuscular injection, although differences were not significant. Extension of use should not take place … Given lorazepam's relatively poor lipid and water solubility, it's not the best candidate for sublingual absorption and so sublingual tablets would need to be designed specifically to deliver lorazepam through the oral mucosa and into systemic circulation. The full sedating effect lasts for around 6 to 8 hours.
For Adult.
Hope that helps.
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50–100 micrograms/kg (max.
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2020
1977 Feb;21(2):222-30. doi: 10.1002/cpt1977212222.Nielsen-Kudsk F, Jensen TS, Magnussen I, Jakobsen P, Jensen PB, Mondrup K, Petersen T.Acta Pharmacol Toxicol (Copenh).
Modes of administration were: A, intravenous injection; B, deltoid intramuscular injection; C, oral tablets in the fasting state; D, sublingual dosage of oral tablets in the fasting state; and E, sublingual dosage of specially formulated tablets in the fasting state. 2017 Feb;31(2):87-95. doi: 10.1007/s40263-016-0403-y.CNS Drugs.
Key facts.
Lorazepam is often used in palliative care to manage anxiety and fear which are common in patients with breathlessness and can otherwise result in a worsening of the situation.
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Treatment to be given: • Under close medical supervision • At the lowest effective dose • For the shortest possible duration (not exceeding 4 weeks) Doses should be individualised.
The following can be considered: lorazepam (scored tablet) sublingual 500 micrograms, given 4 to 6 hourly as required (The Genus, PVL and TEVA brands are all blue, oblong, scored tablets and are suitable for sublingual use). Absolute systemic availability for trials B, C, D, and E averaged 95.9, 99.8, 94.1, and 98.2%, respectively; none of these differed significantly from 100%.