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The renal excretion of beclometasone dipropionate and its metabolites is negligible. Therefore blood glucose should be closely monitored in patients with diabetes.If anaesthesia with halogenated anaesthetics is planned, it should be ensured that Fostair is not administered for at least 12 hours before the start of anaesthesia as there is a risk of cardiac arrhythmias.As with all inhaled medication containing corticosteroids, Fostair should be administered with caution in patients with active or quiescent pulmonary tuberculosis, fungal and viral infections in the airways.It is recommended that treatment with Fostair should not be stopped abruptly.If patients find the treatment ineffective medical attention must be sought. With this inhaler you co-ordinate pressing down the canister and breathing in the spray. By stopping these chemicals being released, beclometasone reduces inflammation in lungs that tightens the airways and makes it difficult for air to get in and out. However studies of the effect of HFA-134a on reproductive function and embryofetal development in animals have revealed no clinically relevant adverse effects.There are no relevant clinical data on the use of Fostair in pregnant womenFostair should only be used during pregnancy if the expected benefits outweigh the potential risks.There are no relevant clinical data on the use of Fostair in lactation in humans.Although no data from animal experiments are available, it is reasonable to assume that beclometasone dipropionate is secreted in milk, like other corticosteroids.While it is not known whether formoterol passes into human breast milk, it has been detected in the milk of lactating animals.Administration of Fostair to women who are breast-feeding should only be considered if the expected benefits outweigh the potential risks.A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Fostair therapy, taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.Fostair is unlikely to have any effect on the ability to drive and operate machinery.As Fostair contains beclometasone dipropionate and formoterol fumarate dihydrate, the type and severity of adverse reactions associated with each of the compounds may be expected.
Based on plasma concentrations measured following inhalation of a single 120 μg dose by 12 healthy subjects, the mean terminal elimination half-life was determined to be 10 hours.
If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR) which have been reported after use of systemic and topical corticosteroids.Beclometasone dipropionate undergoes a very rapid metabolism via esterase enzymes.Beclometasone is less dependent on CYP3A metabolism than some other corticosteroids, and in general interactions are unlikely; however, the possibility of systemic effects with concomitant use of strong CYP3A inhibitors (e.g.
Consideration should be given to the need for increased treatment with corticosteroids, either inhaled or oral therapy, or antibiotic treatment if an infection is suspected.Patients should not be initiated on Fostair during an exacerbation, or if they have significantly worsening or acutely deteriorating asthma.
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Use of cardioselective beta-adrenergic blockers may be considered, but only subject to extreme caution since the use of beta-adrenergic blocker medication may provoke bronchospasm. Fostair inhaler is provided with a counter on the back of the actuator, which shows how many doses are left. Patients should be advised not to expose to temperatures higher than 50°C and not to pierce the canister.Patients should be advised to read the Patient Information Leaflet carefully for cleaning instructions. Do not expose to temperatures higher than 50°C. The second major pathway involves O-demethylation followed by conjugation at the phenolic 2'-hydroxyl group. When suggestions are available use up and down arrows to review and ENTER to select. For the regular cleaning of the inhaler, patients should remove the cap from the mouthpiece and wipe the outside and inside of the mouthpiece with a dry cloth. At the same time, patients should breathe in slowly and deeply through the mouth.
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