";s:4:"text";s:4596:" Of course, your physical appearance and health are also important, and your doctor would not want weight gain to affect your adherence to your depression therapy. SSRI vs NDRI- two different types of med, and yes they work well together. Learn to Spot Depression: Symptoms, Warning Signs, Medication Press question mark to learn the rest of the keyboard shortcuts To further complicate the picture, while many people associate antidepressant use with weight gain, there is actually limited scientific evidence to back this up. I am back in therapy with ways to cope but I just need a little more 'umph'My doctor has suggested Wellbutrin as well and I'm curious as to the weight loss people have had with both and which you would choose. Wellbutrin and Prozac are different types of antidepressants. It was approved by the FDA to treat depression in 1985. Take your doses of Wellbutrin at least 6 hours apart. I don't have a scale, but people have commented that it looks like I've lost weight, and when I look at myself, I definitely see more muscle definition and less fat in my midsection recently. With Prozac, I took whatever the world would dish out, at any time and I could focus on meeting challenging issues with a minimum of anxiety and self doubt. Prozac tends to target serotonin, and wellbutrin tends to target norepinephrine, two of the major neurotransmitters tied to the treatment of depression. I've noticed my self smiling more willing to to out with family and also I'm thinking differently about my life and who I am. The last 3 years I've completely withdrawn from any social activities, relationships & have just been doing the bare minimum to get by. I'm on 80mg of Prozac, 150 mg of seroquil, 10mg brintellex and Wellbutrin (bupropion) 100mg twice a day for depression and OCD. Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol. It is more likely to cause insomnia than drowsiness.