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Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.It is not known whether benzoyl peroxide and clindamycin topical passes into breast milk or if it could harm a nursing baby. If irritancy or dermatitis occurs, reduce frequency of application or temporarily interrupt treatment and resume once the irritation subsides. (Percentages derived by number of subjects receiving Duac Gel with symptom score/number of enrolled subjects receiving Duac Gel).The following adverse reactions have been identified during postapproval use of Duac Gel.
Percent reductions in inflammatory lesion counts after treatment for 11 weeks in these 5 trials are shown in Table 2.The group treated with Duac Gel showed greater overall improvement in the investigator’s global assessment than the benzoyl peroxide, clindamycin, and vehicle groups in three of the five trials (Trials 1, 2, and 5).Clinical trials have not adequately demonstrated the effectiveness of Duac Gel versus benzoyl peroxide alone in the treatment of non-inflammatory lesions of acne.Duac Gel is a white to slightly yellow, opaque gel. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.During clinical trials, 397 subjects used Duac Gel once daily for 11 weeks for the treatment of moderate to moderately severe facial acne vulgaris. Throw away any unused medicine after the Apply the missed dose as soon as you remember. Duac Gel applied once daily for 11 weeks was significantly more effective than vehicle, benzoyl peroxide, and clindamycin in the treatment of inflammatory lesions of moderate to moderately severe facial acne vulgaris in three of the five trials (Trials 1, 2, and 5).Subjects were evaluated and acne lesions counted at each clinical visit at Weeks 2, 5, 8, 11. Available for Android and iOS devices.
Overall, Duac gel is both effective and safe. Call your doctor for medical advice about side effects.
The clinical significance of this in vitro antagonism is not known.Concomitant topical acne therapies should be used with caution since a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents. Avoid getting this medicine in your eyes, mouth, or nose (or in the creases of your nose), or on your lips. (clindamycin phosphate and benzoyl peroxide) Gel, 1.2%/5%We comply with the HONcode standard for trustworthy health information - DUAC is usually applied twice daily, in the morning and evening. Fertility studies in rats treated orally with up to 300 mg per kg per day of clindamycin (approximately 120 times the amount of clindamycin in the highest recommended adult human dose of 2.5 g Duac Gel, based on mg per mIn five randomized, double-blind clinical trials of 1,319 subjects, 397 used Duac Gel, 396 used benzoyl peroxide, 349 used clindamycin, and 177 used vehicle.
Treatment should be discontinued if the irritation persists.Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Do not use anti-diarrhea medicine unless your doctor tells you to.Avoid exposure to sunlight or tanning beds. In vitro studies have shown antagonism between erythromycin and clindamycin.
Avoid the eyes, mouth, lips, mucous membranes, or areas of broken skin.Duac Gel is not for oral, ophthalmic, or intravaginal use.Duac Gel is a white to slightly yellow, opaque gel. You can read patients’ first-hand experiences with the treatment by reading through some of our Duac gel customer reviews .
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