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Acebutolol. Excretion and turnover times in normal donors before and after nephrectomy and in the paired recipient of the kidney after transplantation. ; Flanigan, W.J. Though the medication can … The mechanism most often implicated is inhibition of P-glycoprotein, of which digoxin is a substrate. Clinical Pharmacology and Therapeutics 19: 746–751 (1976).Johnson, B.F.; O’Grady, J.; Sabey, G.A. American Journal of Cardiology 29: 470–474(1972).Doering, W.: Quinidine-digoxin interaction: Pharmacokinetics, underlying mechanism and clinical implications. Clinical Pharmacology and Therapeutics 16: 444–448 (1974a).Greenblatt, D.J.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Check Now » Drug Interaction Categories.
We reviewed the literature, using the standard Prescrire methodology, in order to examine which drugs are involved in these interactions, and the mechanisms involved. Severity of interaction: Moderate Evidence for interaction: Study. Digestive Diseases 16: 903–908 (1971).Hansten, P.D. : Sensitivity to propranolol after digoxin intoxication. Journal of Clinical Pharmacology 19: 692–696 (1979).Steiness, E.: Renal tubular secretion of digoxin. Progress in Cardiovascular Diseases 21: 141–158 (1978).Doherty, J.E. Although most of our knowledge of drug interactions is from data in humans, many of these interactions are likely to occur in dogs and cats as well. COVID-19 is an emerging, rapidly evolving situation. Circulation 58: 1196–1203 (1978).O’Malley, K.; Judge, T.G. Lancet 1: 398–400(1973).Marcus, F.I. Both digoxin and acebutolol can increase the risk of bradycardia. ; Duhme, D.W.; Koch-Weser, J. and Smith, T.W. Contraindicated. Jr.; Murphy, J.E. Fourth Edition, pp.192–199 (Lea and Febiger, Philadelphia 1979).Jelliffe, R.W. Lancet 1: 1473–1475(1973).Johnson, B.F.; Bye, C.; Jones, G. and Sabey, G.A. ; Ayres, J.W. Clipboard, Search History, and several other advanced features are temporarily unavailable. and Doherty, J.E. Some coadministered drugs such as macrolides and cardiovascular drugs (especially amiodarone) can cause digoxin overdose through pharmacokinetic interactions. Circulation 50: 103–107(1974).Waldorff, S.; Andersen, J.D. Severity of interaction: Moderate Evidence for interaction: Study. and Towbin, E.J. Special care is required for patients with renal failure, the elderly and patients receiving potentially interacting drugs. Most relevant data are based on small pharmacokinetic studies or detailed case reports. : Clinical pharmacokinetics of digitalis glycosides. and Bye, C.: Effect of a standard breakfast on digoxin absorption in normal subjects. Clinical Pharmacology and Therapeutics 26: 21–23(1979).Department of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, 52242, USADepartment of Pharmacy Practice, University of Pittsburg, Pittsburg, USAYou can also search for this author in : Effect of serum potassium level upon risk of digitalis toxicity. These studies have demonstrated significant reduction of absorption of oral digoxin by simultaneously administered liquid antacids, cholestyramine, kaolin-pectin, and meals of high fibre content. ; Blackstone, M.O. ; Dalrymple, G.V. Digoxin has a well-defined interaction with aluminum-salt--based antacid treatments, such as aluminum hydroxide, kaolin-pectin and other stomach-coating medications. New England Journal of Medicine 295: 1034–1037(1976).Brown, D.D.
: Current status of therapy with digoxin. : Influence of kaolin-pectin suspension on digoxin bioavailability. An interaction is when a substance changes the way a drug works. Aspirin has been shown to raise serum digoxin levels in the dog. The major pharmacodynamic interactions include potentiation of digitalis toxicity by potassium-wasting diuretics and by succinlycholine. : Drug interactions. Jr.: Variation in biologic availability of digoxin from four preparations. Multiple drug administration may affect the actions of digoxin either by altering its myocardial effects (dose-response relationship or pharmacodynamic effect) or by altering the absorption, storage or excretion of the drug (a pharmacokinetic effect). Clinical Research 27: 610A (1979).Brown, D.D. Multiple drug administration may affect the actions of digoxin either by altering its myocardial effects (dose-response relationship or pharmacodynamic effect) or by altering the absorption, storage or excretion of the drug (a pharmacokinetic effect).
Hypercalcaemia and hypokalaemia inducing drugs, heart-rate lowering drugs, and drugs that prolong the QT interval or slow cardiac conduction can potentiate the cardiac adverse effects of digoxin.
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