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Nephron 63 (1993): 47111. Loftus CG, Loftus EV, Tremaine WJ, Sandborn WJ "The safety profile of Azathioprine (AZA)/6-Mercaptopurine (6-MP) in the treatment of inflammatory bowel disease (IBD): a population-based study in Olmsted County, Minnesota." Limited data are available on the use of oral itraconazole in patients with hepatic impairment. This individual benefit/risk assessment should take into consideration factors such as the severity of the indication, the dosing regimen (e.g. J Intern Med 227 (1990): 69-726. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Keystone EC, Schabas R "Hypotension with oliguria: a side-effect of azathioprine." By continuing to browse the site you are agreeing to our policy on the use of cookies. Clin Lab Haematol 16 (1994): 285-946. Active substance: azathioprine. A single-centre experience from Australia."
(See section 5.2 When appropriate, it is recommended that plasma concentrations be measured.Examples of drugs that may have their plasma concentrations increased by itraconazole presented by drug class with advice regarding coadministration with itraconazole:colchicine, in subjects with renal or hepatic impairmentCoadministration of itraconazole with the NSAID meloxicam may decrease the plasma concentrations of meloxicam.
Compton MR, Crosby DL "Rhabdomyolysis associated with azathioprine hypersensitivity syndrome." HermannsLe T, Pierard GE "Azathioprine-induced skin peeling syndrome." The duration of treatment should be based upon the status of the immune recovery. Major GA, Moore PG "Profound circulatory collapse due to azathioprine." patients with achlorhydria) or from concomitant medication (e.g. Ann Rheum Dis 41 (1982): 37-926. Katska DA, Saul SH, Jorkasky D, Sigal H, Reynolds JC, Soloway RD "Azathioprine and hepatic venocclusive disease in renal transplant patients." Liano F, Moreno A, Matesanz R, et al "Veno-occlusive hepatic disease of the liver in renal transplantation: is azathioprine the cause?" Activated charcoal may be given if considered appropriate. It is recommended that liver function monitoring be done in patients with pre-existing hepatic function abnormalities or those who have experienced liver toxicity with other medications. Kerstens PJ, Stolk JN, Hilbrands LB, Vandeputte LB, Deabreu RA, Boerbooms AM "5-nucleotidase and azathioprine-related bone-marrow toxicity." total daily dose), and individual risk factors for congestive heart failure. Transplantation 47 (1989): 293-643. Ann Rheum Dis 47 (1988): 503-59. It is recommended that the prolonged elimination half-life of itraconazole observed in the single oral dose clinical trial with itraconazole capsules in cirrhotic patients be considered when deciding to initiate therapy with other medications metabolised by CYP3A4.In patients with elevated or abnormal liver enzymes or active liver disease, or who have experienced liver toxicity with other drugs, treatment with Sporanox is strongly discouraged unless there is a serious or life threatening situation where the expected benefit exceeds the risk. Product Name (in authorisation country) MRP/DCP Authorisation number National Authorisation Number MAH of product in the Cassinotti A, Massari A, Ferrara E, et al. Clin Exp Dermatol 20 (1995): 353-676. Hepatotoxicity is often manifest as cholestasis and/or acute focal hepatocellular necrosis, and is generally reversible following discontinuation of azathioprine therapy. Impaired absorption in AIDS and neutropenic patients may lead to low itraconazole blood levels and lack of efficacy. Transplant Proc 19 (1987): 3699-70359. Floyd A, Pedersen L, Lauge Nielsen G, Thorlacius-Ussing O, Toft Sorensen H "Risk of acute pancreatitis in users of azathioprine: a population-based case-control study."
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