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Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.Biologically inactive clindamycin phosphate is converted to active clindamycin. Therefore, it should be used with caution in patients receiving such agents.Clindamycin is metabolized predominantly by CYP3A4, and to a lesser extent by CYP3A5, to the major metabolite clindamycin sulfoxide and minor metabolite N-desmethylclindamycin. These reactions can be minimised by deep i.m. When necessary, pH is … When the equivalent of 300 mg of clindamycin is injected intramuscularly, a mean peak plasma concentration of 6 microgram/ml is achieved within three hours; 600 mg gives a peak concentration of 9 microgram/ml. However, periodic liver enzyme determinations should be made when treating patients with severe liver disease.Prescribing clindamycin phosphate in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.Patients should be counseled that antibacterial drugs including clindamycin phosphate should only be used to treat bacterial infections. ANY UNUSED PORTION MUST BE DISCARDED WITHIN 24 HOURS AFTER INITIAL ENTRY.Each mL of Clindamycin Injection, USP contains clindamycin phosphate equivalent to 150 mg clindamycin, 0.5 mg disodium edetate, 9.45 mg benzyl alcohol added as preservative.
Generalised mild to moderate morbilliform-like skin rashesGeneral disorders and administration site conditionsLocal irritation, pain, abscess formation at the place of injection after intramuscular administration. It is not effectively removed from the blood by dialysis.Solutions of clindamycin salts have a low pH and incompatibilities may reasonably be expected with alkaline preparations or drugs unstable at low pH. Doses of as much as 4800 mg daily have been given intravenously to adults (see Single intramuscular injections of greater than 600 mg are not recommended.Alternatively, drug may be administered in the form of a single rapid infusion of the first dose followed by continuous IV infusion as follows:15 to 20 mg/kg/day in 3 to 4 equal doses.
In the presence of strong CYP3A4 inhibitors, monitor for adverse reactions.
Because of the risk of antibiotic-associated pseudomembranous colitis, as described in the Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to clindamycin.Indicated surgical procedures should be performed in conjunction with antibiotic therapy.Clindamycin phosphate is indicated in the treatment of serious infections caused by susceptible strains of the designated organisms in the conditions listed below:Lower respiratory tract infections including pneumonia, empyema, and lung abscess caused by anaerobes, Gynecological infections including endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection caused by susceptible anaerobes.Intra-abdominal infections including peritonitis and intra-abdominal abscess caused by susceptible anaerobic organisms.Bone and joint infections including acute hematogenous osteomyelitis caused by To reduce the development of drug-resistant bacteria and maintain the effectiveness of clindamycin phosphate and other antibacterial drugs, clindamycin phosphate should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Monitor the breast-fed infant for possible adverse effects on the gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis.The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for clindamycin and any potential adverse effects on the breast-fed child from clindamycin or from the underlying maternal condition.When Clindamycin Injection is administered to the pediatric population (birth to 16 years) appropriate monitoring of organ system functions is desirable.This product contains benzyl alcohol as a preservative. If not used immediately, in-use storage times and conditions are the responsibility of the user and would normally be no longer than 24 hours at 2-8°C unless dilution has taken place in controlled and validated aseptic conditions.The product should not be admixed with other drug products which are chemically or physically unstable at low pH (see section 6.2).The compatibility and duration of stability of drug admixtures will vary depending upon concentration and other conditions.The Old Dairy, Brynkinalt Business Centre, Brynkinalt, Chirk, Wrexham, LL14 5NS, UKTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in.
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