";s:4:"text";s:3685:"Taking Heart Drugs? Selective serotonin uptake inhibitors ( SSRIs): Prozac (fluoxetine) and Paxil (paroxetine) are strong inhibitors of CYP2D6. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. However, one study reported that secretions from adipose stem cells of obese women were able to counteract the treatment effects of tamoxifen, suggesting that being overweight could contribute to tamoxifen resistance. While it is not clear that reducing dietary cholesterol would greatly affect this process, it may make sense for breast cancer patients on tamoxifen to reduce their cholesterol to low-normal levels.It has been reported that tamoxifen use in breast cancer survivors is associated with an increased risk of The following foods (or major components) have been found to increase the anti-breast cancer effects of tamoxifen treatment:The following foods (or major components) and supplements have been found to reduce the effectiveness of tamoxifen and should be avoided during tamoxifen treatment:There is also some evidence that exposure to bisphenol A (The following foods (or major components) have been associated with lower risk of endometrial cancer while also protecting against breast cancer:The foods and supplements listed below have been associated with increased risk of endometrial cancer. This list covers only some interactions. Some can interact with prescription medications used to treat heart and circulatory problems, such as high blood pressure and heart failure. Some drugs strongly inhibit the enzyme so that little if any endoxifen is produced when they are taken with tamoxifen. Tamoxifen targets not only the estrogen receptors in breast tissue, but also all of the other cells in the body that have estrogen receptors. One of the things that most women who are going through breast cancer treatments complain about (and being a breast cancer coach, I do hear these complaints every single day) is all of the side effects of Tamoxifen and other aromatase inhibitor drugs. A single copy of these materials may be reprinted for noncommercial personal use only. Some of these interactions can even be dangerous.About one-half of adults in the United States report having used at least one dietary supplement in the previous month. If you take statins to improve your blood cholesterol levels, some supplements may interfere with the effectiveness of statins or increase your risk of side effects, some potentially life-threatening. Medications that should be avoided with tamoxifen include: 1. Severe Interactions. Lynne Eldrige, MD, is a lung cancer physician, patient advocate, and award-winning author of "Avoiding Cancer One Day at a Time." Description and Brand Names. Of note is the variation in the extent to which these may reduce the effectiveness of tamoxifen; some are very strong inhibitors of CYP2D6, whereas others inhibit the enzyme to lesser degrees. There may be times when the benefits of using one of these options may outweigh the risk of reducing your endoxifen levels.