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";s:4:"text";s:4871:"Patients with rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose-galactose malabsorption should not take this medicine.This medicinal product contains small amounts of ethanol (alcohol), less than 100 mg per dose. Clindamycin capsules are not suitable for children who are unable to swallow them whole. It allows continued monitoring of the benefit/risk balance of the medicinal product, Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.In cases of overdosage no specific treatment is indicated.Gastric decontamination is not necessary. Similarly, if previous prophylaxis with mefloquine has failed, Lariam should not be used for curative treatment.In pediatric patients, the administration of Lariam for the treatment of malaria has been associated with early vomiting. Mefloquine and its main metabolite are not appreciably removed by hemodialysis. All surviving rats given 30 mg/kg/day had ocular lesions in both eyes characterized by retinal degeneration, opacity of the lens, and retinal edema. Over 90% of clindamycin in the circulation is bound to plasma proteins. These effects may occur after therapy is discontinued due to the long half-life of the drug. If you would like more information, talk with your doctor. Rare cases of suicidal ideation and suicide have been reported though no relationship to drug administration has been confirmed.Other less frequently reported adverse events include:The most frequently observed laboratory alterations which could be possibly attributable to drug administration were decreased hematocrit, transient elevation of transaminases, leukopenia and thrombocytopenia. Absorption of Clindamycin is not appreciably modified by the presence of food.Clindamycin is contra-indicated in patients previously found to be sensitive to Clindamycin, lincomycin, or to any excipient listed in Section 6.1 (List of excipients).Clindamycin should not be used in patients with existing diarrhoea.Severe hypersensitivity reactions, including severe skin reactions such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalised exanthematous pustulosis (AGEP) have been reported in patients receiving clindamycin therapy. Antagonism has been demonstrated between clindamycin and erythromycin Clindamycin antagonises the effects of the above anticholinesterases.Oral typhoid vaccine is inactivated by concomitant administration of antibacterials. You may report side effects to FDA at 1-800-FDA-1088.Keep Lariam and all medicines out of the reach of children.Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Other measures should be taken as indicated by the patient's clinical condition. To reduce the risk of malaria after leaving an endemic area, prophylaxis must be continued for 4 additional weeks to ensure suppressive blood levels of the drug when merozoites emerge from the liver. See section 4.4 for other factors which should be taken into consideration.The usual dose is 3 - 6 mg/kg every six hours depending on the severity of the infection. The disease is likely to follow a more severe course in older patients or patients who are debilitated. Mefloquine may accumulate in parasitized erythrocytes. In rabbits, a high dose of 160 mg/kg/day was embryotoxic and teratogenic, and a dose of 80 mg/kg/day was teratogenic but not embryotoxic. Its exact mechanism of action is not known.Mefloquine is active against the erythrocytic stages of Cross-resistance between mefloquine and halofantrine and cross-resistance between mefloquine and quinine have been observed in some regions.Lariam is indicated for the treatment of mild to moderate acute malaria caused by mefloquine-susceptible strains of Use of Lariam is contraindicated in patients with a known hypersensitivity to mefloquine or related compounds (eg, quinine and quinidine) or to any of the excipients contained in the formulation. Neonates (0-28 days), especially if premature, require special attention to dose reductions and/or extended dose intervals due to the prolonged elimination half-life.Clindamycin capsules are not suitable for children who are unable to swallow them whole. Give oral fluids for severe vomiting and diarrhoea if required. The capsules do not provide exact mg/kg doses therefore it may be necessary to use the parenteral formulation in some cases. This information does not take the place of talking to your doctor about your medical condition or your treatment.In some patients these serious side effects can go on after Lariam is stopped.Lariam is a prescription medicine used to prevent and treat malaria. 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