";s:4:"text";s:5312:"The overall incidence of side effects was similar between Ezetimibe and placebo. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.The presence of other medical problems may affect the use of this medicine. (See section 4.8. (See section 4.8)In a controlled clinical study in which over 9000 patients with chronic kidney disease were randomized to receive Ezetimibe 10 mg combined with simvastatin 20 mg daily (n=4650) or placebo (n=4620), (median follow-up period of 4.9 years), the incidence of consecutive elevations of transaminases (>3 X ULN) was 0.7% for ezetimibe combined with simvastatin and 0.6% for placebo (see section 4.8).In post-marketing experience with ezetimibe tablets, cases of myopathy and rhabdomyolysis have been reported. Studies in women breastfeeding have demonstrated harmful infant effects. You should not use ezetimibe if you have moderate to severe liver disease. Ezetimibe inhibited the absorption of [Epidemiologic studies have established that cardiovascular morbidity and mortality vary directly with the level of total-C and LDL-C and inversely with the level of HDL-C.Administration of Ezetimibe with a statin is effective in reducing the risk of cardiovascular events in patients with coronary heart disease and ACS event history.In controlled clinical studies, ezetimibe, either as monotherapy or co-administered with a statin significantly reduced total cholesterol (total-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and trigylcerides (TG) and increased high-density lipoprotein cholesterol (HDL-C) in patients with hypercholesterolaemia.In a double-blind, placebo-controlled, 8-week study, 769 patients with hypercholesterolaemia already receiving statin monotherapy and not at National Cholesterol Education Program (NCEP) LDL-C goal (2.6 to 4.1 mmol/l [100 to 160 mg/dl], depending on baseline characteristics) were randomised to receive either ezetimibe 10 mg or placebo in addition to their ongoing statin therapy.Among statin-treated patients not at LDL-C goal at baseline (~82%), significantly more patients randomised to ezetimibe achieved their LDL-C goal at study endpoint compared to patients randomised to placebo, 72% and 19% respectively. Results for the two treatment groups were similar for TG and HDL-C (-6% vs. +8%, and +2% vs. +1%, respectively).In a multicentre, double-blind, controlled study, 142 boys (Tanner stage II and above) and 106 postmenarchal girls, 10 to 17 years of age (mean age 14.2 years) with heterozygous familial hypercholesterolaemia (HeFH) with baseline LDL-C levels between 4.1 and 10.4 mmol/l were randomised to either ezetimibe 10 mg co-administered with simvastatin (10, 20 or 40 mg) or simvastatin (10, 20 or 40 mg) alone for 6 weeks, co-administered ezetimibe and 40 mg simvastatin or 40 mg simvastatin alone for the next 27 weeks, and open-label co-administered ezetimibe and simvastatin (10 mg, 20 mg, or 40 mg) for 20 weeks thereafter.At Week 6, ezetimibe co-administered with simvastatin (all doses) significantly reduced total-C (38 % vs 26 %), LDL-C (49 % vs 34 %), Apo B (39 % vs 27 %), and non-HDL-C (47 % vs 33 %) compared to simvastatin (all doses) alone. )In the IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT), 18,144 patients with coronary heart disease and ACS event history were randomised to receive ezetimibe/simvastatin 10/40 mg daily (n=9067) or simvastatin 40 mg daily (n=9077). Take the medicine at the same time each day.Ezetimibe may be taken at the same time with fenofibrate, or with a statin medication such as atorvastatin, lovastatin, simvastatin, pravastatin, or fluvastatin.If you also take cholestyramine, colestipol, or colesevelam: You may take ezetimibe 2 hours before taking any of these medicines or wait at least 4 hours after taking any of these other medicines.You may need frequent blood tests to check your liver function if you take ezetimibe with a statin medicine.It may take up to 2 weeks before your cholesterol levels improve. The co-administration of ezetimibe with lovastatin resulted in embryolethal effects.This medicinal product does not require any special temperature storage conditions.Store in the original package in order to protect from moisture.PVC/PVDC/Aluminumblister: Blister pack containing 28, 30, 50, 90, 98 and 100 tablets.OPA/Aluminum/PVC/Aluminum blister: Blister pack containing 28, 30, 50, 90, 98 and 100 tablets.Capital House, 85 King William Street, London EC4N 7BL,Capital House, 1st Floor, 85 King William Street, London, EC4N 7BL, UKTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. statins, bile acid sequestrants [resins], fibric acid derivatives, and plant stanols). Ezetimibe coadministered with atorvastatin (40 or 80 mg) or simvastatin (40 or 80 mg), significantly reduced LDL-C by 15% compared with increasing the dose of simvastatin or atorvastatin monotherapy from 40 to 80 mg.The Study of Heart and Renal Protection (SHARP) was a multi-national, randomized, placebo-controlled, double-blind study conducted in 9438 patients with chronic kidney disease, a third of whom were on dialysis at baseline. ";s:7:"keyword";s:20:"ezetimibe dose arava";s:5:"links";s:3553:"Haagen-dazs Recall 2019 Zithromax,
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