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36th Annual Meeting of the American Society of Clinical Oncology; 2000 May 20–23; New Orleans, LAVan Cutsem E, Findlay M, Osterwalder B, et al. A phase I study of capecitabine in combination with oral leucovorin in patients with intractable solid tumors. J Clin Oncol 1997; 15: 110–5Gunasekara NS, Faulds D. Raltitrexed: a review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer. Fluoropyrimidines in the treatment of advanced neoplastic diseases: role and advantages of UFT. Rates of disease stabilisation were slightly higher in those receiving intermittent and combination capecitabine than in those receiving continuous capecitabine.Phase I and II studies of first-line treatment with capecitabine in combination with other antineoplastic therapies, notably oxaliplatin, have shown encouraging response rates.The tolerability profile of capecitabine is typical of infusional fluoropyrimidines and adverse effects are primarily of a gastrointestinal nature. J Clin Oncol 2000 Mar; 18: 1337–45Schleucher N, Tewes M, Achterrath W, et al. Importantly, patients spent less time in hospital after capecitabine than after bolus fluorouracil and leucovorin therapy, and the oral route of administration of capecitabine is likely to be preferred.In conclusion, capecitabine has shown superior tumour response and less myelosuppression, although more grade 3 hand-and-foot syndrome, in comparison with the ‘Mayo Clinic’ regimen of fluorouracil therapy, but is unlikely to improve survival.
Clin Cancer Res 1999 Jul; 5: 1696–702Reigner B, Clive S, Cassidy J, et al.
J Clin Oncol 2001; 19: 4097–106Hoff P, Abbruzzese JL, Medgyesy D, et al. Improved tolerability and comparable efficacy compared with IV FU/LV in addition to oral administration make capecitabine an attractive option for the treatment of several types of cancers as well as the focus of future trials.We use cookies to help provide and enhance our service and tailor content and ads. Over 10 million scientific documents at your fingertips Colon cancer r(PDQ): treatment — health professionals [online]. Response rates were also higher in patients pretreated in the adjuvant setting and whose primary site of metastasis was the lung. Route of Elimination: Capecitabine and its metabolites are predominantly excreted in urine; 95.5% of administered capecitabine dose is recovered in urine.
In patients pretreated in the adjuvant setting, the overall response rate was doubled in those receiving capecitabine and tripled in patients whose primary site of metastasis was the lung compared with fluorouracil and leucovorin (21.1 In a randomised phase II study, intermittent capecitabine therapy achieved overall response rates (24%) which were similar to those achieved with continuous capecitabine therapy (21%) and capecitabine in combination with leucovorin (23%) in patients previously untreated for metastatic colorectal cancer. Clin Cancer Res 1998; 4: 2755–61Cassidy J, Twelves C. Effective dose-modification (DM) scheme for the management of toxicities with capecitabine therapy: data from metastatic colorectal cancer (mCRC) phase III trials. However, no significant differences between the two treatment groups were seen in the time to disease progression, time to treatment failure or overall survival.Preliminary data suggest response may be improved by combining capecitabine with other anticancer therapies such as oxaliplatin, irinotecan and radiotherapy.Capecitabine in therapeutic dosage regimens generally has acceptable tolerability. 4: 60Hoff P. Capecitabine as first-line treatment for metastatic colorectal cancer (CRC): integrated results of 1207 patients (pts) from 2 randomized, phase III studies [poster]. BMJ 2000; 321: 805–8National Institutes of Health. Search terms included Capecitabine is an oral prodrug that is converted to its only active metabolite, FU, by thymidine phosphorylase. The drug is also approved for use as (1) a single agent in metastatic breast cancer patients who are resistant to both anthracycline- and paclitaxel-based regimens or in whom further anthracycline treatment is contra indicated and (2) in combination with docetaxel after failure of prior anthracycline-based chemotherapy. Cancer 1981; 47: 207–14Hoff P. Capecitabine as first-line treatment for colorectal cancer (CRC): integrated results of 1207 patients (pts) from 2 randomized, phase III studies.
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