doi: 10.1007/s12028-015-0230-x Crossref Medline Google Scholar; 14.
Nimodipine (Nimotop), a calcium channel blocker, is indicated to reduce the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial aneurysms.1 It improves neurological outcome by relaxing cerebral smooth muscle vasculature and preventing vasospasm.
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Controlled studies in pregnant women show no evidence of fetal risk.Metabolites interfere with malignant cell growth by cross-linking tumor cell DNA; drug does not have specificity for any phase of the cell cycle; also has potent immunosuppressive activityPeak plasma time: Cyclophosphamide, 1 hr; metabolites, 2-3 hrProtein bound: Cyclophosphamide, low; metabolites, >60%Metabolites: 4-hydroperoxycyclophosphamide, 4-aldophosphamidePatients should drink plenty of fluids with PO dosesPatients should empty bladder frequently to prevent hemorrhagic cystitisSometimes, mesna is used concomitantly as prophylaxis against hemorrhagic cystitisMonitor blood counts during therapy (WBC count may decrease to 2000-3000/μL without serious risk of infection)May be administered IM, intraperitoneally, intrapleurally, by IV piggy-back, or by continuous IV infusion Additive: Cisplatin/etoposide, fluorouracil, hydroxyzine, methotrexate, methotrexate/fluorouracil, mitoxantrone, ondansetronSyringe: Bleomycin, cisplatin, doxapram, doxorubicin, droperidol, furosemide, heparin, leucovorin, methotrexate, metoclopramide, mitomycin, vinblastine, vincristineY-site (partial list): Allopurinol, amifostine, bleomycin, most cephalosporins, cisplatin, diphenhydramine, doxorubicin, doxorubicin liposomal, filgrastim, fluorouracil, furosemide, gemcitabine, linezolid, lorazepam, mitomycin, morphine, paclitaxel, prochlorperazine, propofol, sodium bicarbonate, trimethoprim/sulfamethoxazole, vancomycin, vinblastine, vincristineMaximum concentration of cyclophosphamide is limited to 20 mg/mL because of solubilityIV push: Reconstitute with NS (do not use SWI, because it is hypotonic)Infusion: Reconstitute with SWI to concentration of 20 mg/mLMay dilute further with D5W, NS, lactated Ringer solution, or other compatible fluidsDoses >500 mg up to ~1 g may be administered over 20-30 minutesTo minimize bladder toxicity, increase normal fluid intake during and for 1-2 days after cyclophosphamide therapy; most adult patients will require fluid intake of at least 2 L/day; high-dose regimens should be accompanied by vigorous hydration with or without mesna therapyAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Patients were consecutively allocated to 1 of the 3 treatments in a …
Nimodipine 60 mg every four hours is administered to all patients with aneurysmal subarachnoid hemorrhage, ideally within four days of SAH.The typical dose is 60 mg every four hours by mouth or nasogastric tube.Nimodipine must be given orally or by nasogastric tube because inadvertent intravenous administration has been associated with serious adverse events, including death.
2016; 25:29–39. Epub 2014 Nov 11.Can J Hosp Pharm. Patients received intravenous treatment for 5 days, followed by oral treatment for an additional 16 days.
Online ahead of print.McBride DW, Blackburn SL, Peeyush KT, Matsumura K, Zhang JH.Front Neurol. eCollection 2017. Clipboard, Search History, and several other advanced features are temporarily unavailable. Paľa A, Schick J, Klein M, Mayer B, Schmitz B, Wirtz CR, König R, Kapapa T.J Neurosurg.
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High-dose: 500-1000 mg/m² IV monthly for 6 doses plus corticosteroids. and formulary information changes. Unable to load your delegates due to an error