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If you have any questions, ask your doctor or pharmacist.Take this medication by mouth with a meal as directed by your doctor, usually once daily. In a study conducted in rats, there were no effects on mating or fertility with rilpivirine up to 400 mg per kg per day, a dose of rilpivirine that showed maternal toxicity.
To help you remember, take this medication at the same time every day.Do not take more or less of this drug than prescribed or stop taking it even for a short time unless directed to do so by your doctor.
Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.
(The most common adverse reactions (all grades) observed in at least 2% of subjects were diarrhea and headache. Strand transfer biochemical assays using purified HIV-1 integrase and pre-processed substrate DNA resulted in ICRilpivirine is a diarylpyrimidine NNRTI of HIV-1 and inhibits HIV-1 replication by non-competitive inhibition of HIV-1 reverse transcriptase (RT). In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This information is not individual medical advice and does not substitute for the advice of your health care professional.
Ranitidine: JULUCA should only be administered at least 4 hours before or 12 hours after taking H 2-receptor antagonists. 404: Scholler-Gyure M, Kakuda TN, De Smedt G, et al.
Neither dose of dolutegravir had a significant effect on the actual glomerular filtration rate (determined by the clearance of probe drug, iohexol) or effective renal plasma flow (determined by the clearance of probe drug, para-amino hippurate) compared with the placebo.The pharmacokinetic (PK) properties of the components of JULUCA are provided in Population pharmacokinetic analyses indicated that mild renal impairment had no clinically relevant effect on the exposure of rilpivirine. Taking dolutegravir and lamivudine during the first trimester of … Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of:Rilpivirine may cause a condition that affects the heart rhythm (QT prolongation). Advise pregnant individuals of the potential risk to the embryo exposed to JULUCA from the time of conception through the first trimester of pregnancy.
Discontinued for other reasons while not <50 copies/mLTreatment differences were maintained across baseline characteristics including, CD4+ cell count, age, gender, race, and baseline third-treatment-agent class.Each JULUCA tablet contains 50 mg of dolutegravir and 25 mg of rilpivirine, and is a pink, oval, film-coated, biconvex tablet debossed with “SV J3T” on one side.Bottle of 30 tablets with child-resistant closure (contains a desiccant) NDC 49702-242-13.Store and dispense in the original package, protect from moisture, and keep the bottle tightly closed. JULUCA should only be administered at least 4 hours before or 12 hours after taking H 2-receptor antagonists.
Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Moderate. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are:Do not take this medication with other products that treat HIV infection. Version: 6.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The long-term clinical significance of these BMD changes is not known.Fractures (excluding fingers and toes) were reported in 3 (0.6%) subjects who switched to dolutegravir plus rilpivirine and 9 (1.8%) subjects who continued their current antiretroviral regimen through 48 weeks.In the pooled Phase 3 trials results analysis of rilpivirine, at Week 96, there was an overall mean change from baseline in basal cortisol of -0.69 (-1.12, 0.27) micrograms/dL in the rilpivirine group and of -0.02 (-0.48, 0.44) micrograms/dL in the efavirenz group. Data from an observational birth outcome surveillance study in Botswana (Tsepamo study) showed an increased risk of neural tube defects associated with use of dolutegravir-containing regimens at time of conception and during early pregnancy compared with use of antiretroviral regimens that did not contain dolutegravir.
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