";s:4:"text";s:4447:" The deposits typically resolve with discontinuation of the responsible agents. To compare the morphology of two types of vortex keratopathy: amiodarone-induced keratopathy and the Fabry disease-associated keratopathy. After 10 months of a daily dose of 100 mg of amiodarone, one patient presented with a bilateral verticillate keratopathy. Eight patients who were receiving oral amiodarone therapy and 3 patients with Fabry disease, a mother and her 2 daughters, were examined by slit-lamp biomicroscopy and in vivo confocal microscopy (IVCM) regularly. There is no recommended treatment for cornea verticillata. Graefes Arch Clin Exp Ophthalmol, 249 (11)(2011), pp. Band keratopathy is thought to be caused from conditions that increase the levels of calcium in the body such as kidney disease, excessive vitamin D, increased levels of certain thyroid hormones, sarcoidosis, lupus and Paget’s disease, a condition where there is an excessive breakdown of your bones. Purpose . Some reports may have incomplete information.Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. ... Pitz S. Confocal laser-scanning microscopy allows differentiation between Fabry disease and amiodarone-induced keratopathy. Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion (Fig 12-15).A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties. Patients and Methods .
You can see these as a whorl pattern – the entity is also called whorl keratopathy or hurricane keratopathy.
Drugs that can cause this pattern: CACTI Mneumonic: chloroquine, amiodarone, chlorpromazine, tamoxifen, […] The differential diagnosis of corneal verticillata should also include Fabry disease, a disorder of sphingolipid metabolism.